Liver

People with the Pi Z gene produce a slightly different form of alpha-1 antitrypsin protein in their liver which becomes trapped and can cause irreversible liver damage.

Several different types of liver conditions can be associated with alpha-1 antitrypsin deficiency. These are explained in more detail in this document:- Information programme - Liver.

If you have a child with liver problems then you may wish to go to the page Apha1 Children